Introduction: Rheumatoid arthritis (RA) is defined as a chronic immune-mediated disease and the Botox is tried to be a new treatment. The aim of our work to compare the ameliorating actions of the peri-articular Botox as a new modality and the systematic corticosteroids on the rheumatoid arthritis in the adult albino rats. Materials and methods: Rats were randomly allocated into 5 weight-matched groups, each of 5 rats; Group 1: ten rats were divided into the negative control were left without any intervention and the positive control were injected intra-articularly with saline, Group 2 induced RA by injecting rats with Freund's Complete Adjuvant (CFA), Group 3 were injected with Botox together with CFA and Group 4 were injected with dexamethasone (DEX) with CFA. Results: the RA induced rats showed significant improvement histologically, biochemically and radiologically when given corticosteroids with mild amelioration when given Botox. Conclusion: we have concluded that the use of Botox and dexamethasone were effective therapies of the RA with the priority to dexamethasone in the management of the RA.