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329943

Effect of Metalaxyl on the thyroid gland in adult female albino rats and the possible protective role of ginger (Histological and immunohistochemical study)

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Last updated: 23 Dec 2024

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Abstract

Introduction: Metalaxyl is a widely used fungicide, with high residual level in crops that lead to dangerous human health
problems.
Aim of work: Study effect of metalaxyl on the thyroid gland structure& function and evaluate the efficacy of ginger
supplementation.
Materials and Methods: Thirty female albino rats were classified into three equal groups: Group I: (control group): Subdivided
into two equal subgroups 1a: given distilled water by gastric tube for 8 weeks. 1b: given ginger (100mg/kg/day) by gastric tube
for 8 weeks. Group II: given metalaxyl 3 times per week (130 mg/kg/day) by gastric tube for 8 weeks. Group III: given the
same dose of metalaxyl given to group II concomitant with ginger by gastric tube for 8 weeks. At end of the experiment, rats
were anaesthetized, and blood samples collected for measurement of T3, T4 and TSH. Thyroid gland biopsies were processed
for light and electron microscope examination. Immunohistochemical study was done for detection of PCNA. Results were
analyzed morphometrically and statistically.
Results: Metalaxyl-treated rats showed numerous interfollicular cells, vacuolated colloid, an increase height of follicular
epithelium and many follicles exhibited stratification with vacuolated cytoplasm, dilatations of endoplasmic reticulum and
irregular dark nuclei. Positive immunoreaction was detected in numerous nuclei of follicular cells of group II and significant
decrease in T3, T4 with highly increase in TSH. Group III showed a considerable degree of improvement of thyroid architecture.
Conclusion: Metalaxyl affects the thyroid follicular structure and function. Concomitant administration of ginger was partially
efficient in protecting it.

DOI

10.21608/jmh.2022.174227.1107

Keywords

Ginger, Metalaxyl, PCNA, THYROID

Authors

First Name

Sahar

Last Name

Shaban

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Affiliation

Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Egypt.

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First Name

Azza

Last Name

Shehata

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Affiliation

Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Egypt.

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Orcid

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First Name

Aisha

Last Name

Elkhodary

MiddleName

-

Affiliation

Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Egypt.

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First Name

Abeer

Last Name

Mahmoud

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-

Affiliation

Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Egypt.

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Volume

6

Article Issue

2

Related Issue

44750

Issue Date

2022-12-01

Receive Date

2022-11-13

Publish Date

2022-12-01

Page Start

116

Page End

128

Print ISSN

2536-9172

Online ISSN

2536-930X

Link

https://jmh.journals.ekb.eg/article_329943.html

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https://jmh.journals.ekb.eg/service?article_code=329943

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Original Article

Type Code

332

Publication Type

Journal

Publication Title

Journal of Medical Histology

Publication Link

https://jmh.journals.ekb.eg/

MainTitle

Effect of Metalaxyl on the thyroid gland in adult female albino rats and the possible protective role of ginger (Histological and immunohistochemical study)

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Article

Created At

23 Dec 2024