Objective: To evaluate the effect of a preventive bundle on surgical site infection rates in Gynecologic Oncology surgery in Mansoura University Hospital.   
Subjects and methods: Prospective Randomized Controlled Trial that was conducted over a period of 24 months during 2020 and 2022 on 80 patients admitted to Obstetrics and Gynecology department at Mansoura University Hospital. General, abdominal, and pelvic examinations and lab investigations were performed. Randomization of patients into 2 groups: groupI (bundle implementation), groupII (without bundle).    
Results: SSI was more common in group (2) after first week and one month of follow up, and no statistically significant variation in 2ry interventions among SSI cases of the studied groups. There is significant association between BMI and cases of SSI. SSI was more common in cases with BMI more than 25, diabetic cases and cases who received radiotherapy. There is no significant statistical association between SSI and suspected primary pathology of the studied groups, but there is statistically significant association with operative time.
Conclusion: This study showed that implementation of a perioperative surgical site infection prevention bundle was associated with a marked reduction in surgical site infection rate in patients undergoing gynaecological oncology surgeries.