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388588

Effect of metformin on maternal and neonatal outcomes in pregnant obese diabetic patients: New potentials for an old drug

Article

Last updated: 03 Jan 2025

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Abstract

Background: Pregnancy complicated by diabetes whether gestational or pregestational diabetes, could be associated with adverse maternal and neonatal outcomes; if optimum glycemic control was not achieved. Metformin is an insulin sensitizing drug that has been approved for treatment of gestational diabetes and type II pregestational diabetes. In this study, we have studied the role and effectiveness of metformin in improving glycemic control and the prevention of maternal and neonatal adverse outcomes in obese pregnant diabetic women.   
Patient and Methods: This was a prospective cohort study that included 189 obese pregnant diabetic women recruited to Kasr Al Aini Obstetrics and Gynecology department over the period from September 2022 till March 2023. The study population included three groups according to the treatment modality; metformin only group, metformin and insulin group and insulin only group.  
Results: The use of metformin was associated with significant reduction in the incidence of preeclampsia and neonatal lactic acidosis with a p value 0.033 and 0.002 respectively. However, use of metformin whether alone or in addition to insulin, compared to insulin alone was not shown to be superior in improving glycemic control, or reduce adverse neonatal outcomes..  
Conclusion: Metformin use in obese diabetic pregnant women improves maternal and neonatal outcomes. 

DOI

10.21608/egyfs.2024.388588

Keywords

Keywords: Metformin, Diabetes mellitus, Pregnancy, Obesity. 

Authors

First Name

Mariam

Last Name

Dawoud

MiddleName

-

Affiliation

Associate Professor of Obstetrics and Gynecology, Faculty of Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Sediek

MiddleName

Mohamed

Affiliation

Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Cairo University

Email

mona_sediek@yahoo.com

City

-

Orcid

-

First Name

Ayman

Last Name

Hany

MiddleName

-

Affiliation

Professor of Obstetrics and Gynecology, Faculty of Medicine, Cairo University

Email

aymanoo_99@cu.edu.eg

City

-

Orcid

-

First Name

Shaimaa

Last Name

Ahmed

MiddleName

-

Affiliation

Obstetrics and Gynecology Specialist

Email

shaimaa236ahmed@gmail.com

City

-

Orcid

-

First Name

Nada

Last Name

Kamal

MiddleName

-

Affiliation

Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Cairo University

Email

nadakamal@gmail.com

City

-

Orcid

-

Volume

28

Article Issue

5

Related Issue

51208

Issue Date

2024-09-01

Receive Date

2024-10-22

Publish Date

2024-09-01

Page Start

40

Page End

46

Print ISSN

1110-6352

Online ISSN

2536-9768

Link

https://egyfs.journals.ekb.eg/article_388588.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=388588

Order

388,588

Type

Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Effect of metformin on maternal and neonatal outcomes in pregnant obese diabetic patients: New potentials for an old drug

Details

Type

Article

Created At

23 Dec 2024