Beta
363815

Assessment of Galectins -1, -2, -3, and -8 Expression in Endometrial Carcinoma and Its Clinical Implications

Article

Last updated: 23 Dec 2024

Subjects

-

Tags

-

Abstract

Background and aim: Galectins are a type of animal lectins that play a crucial role in regulating various cellular functions that can promote cancer progression including endometrial carcinoma. The aim of this study is to explore the expression of m RNA of galectins 1, 2, 3, and 8 in endometrial cancer and determine their relation to the extent of the disease. 
Methods: This case-control study was carried out at the Ain Shams University Maternity Hospital, as well as in the molecular biology laboratory located in the Zoology Department of the Faculty of Science at Ain Shams University. The study was conducted between October 2019 and January 2022. A total of 72 patients were scheduled for hysterectomy due to endometrial diseases. The study involved two groups. Group 1 comprised 60 women with endometrial malignancy, which includes atypical endometrial hyperplasia and/or endometrioid adenocarcinoma. Group 2 was the control group, which had 12 women with normal endometrial tissues. 58 tumor samples of endometrial pre-cancer and cancer lesions for mRNA expression using qRT-PCR.   
Results: The present study included 58 women with endometrial carcinoma, out of which almost 57% had endometrioid adenocarcinoma. Among them, 37 women were in FIGO stage I and II. The study found that LGALS1, LGALS2, LGALS3, and LGALS8 were significantly over-expressed in endometrial carcinoma patients as compared to the control group. However, the expression of these genes did not differ significantly when compared in different FIGO staging or based on the presence or absence of lymph node metastasis. There was also no significant difference in their expression when comparing patients with either endometrioid or non-endometrioid adenocarcinoma of the uterus.
Conclusion: Our findings support the role of galectins in endometrial carcinogenesis, disease progression, and lymph node metastasis. 
Running title: Galectins in Endometrial Carcinoma

DOI

10.21608/egyfs.2024.363815

Keywords

Keywords: Endometrial carcinoma, galectins, mRNA, qRT-PCR, biomarkers, lymph node metastasis

Authors

First Name

Ahmed

Last Name

Abdel Hamid

MiddleName

Sherif

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

ahmedgyna@yahoo.com

City

-

Orcid

-

First Name

Radwa

Last Name

Mohamed

MiddleName

M M Z

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Hany

Last Name

Naeam

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Abdelfattah

MiddleName

M.

Affiliation

Molecular Cancer Biology group, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

Ghonim

MiddleName

A

Affiliation

Molecular Cancer Biology group, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Kortam

MiddleName

A M F

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Reham

Last Name

Helwa

MiddleName

-

Affiliation

Molecular Cancer Biology group, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

28

Article Issue

3

Related Issue

48865

Issue Date

2024-05-01

Receive Date

2024-07-04

Publish Date

2024-05-01

Page Start

11

Page End

25

Print ISSN

1110-6352

Online ISSN

2536-9768

Link

https://egyfs.journals.ekb.eg/article_363815.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=363815

Order

3

Type

Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Assessment of Galectins -1, -2, -3, and -8 Expression in Endometrial Carcinoma and Its Clinical Implications

Details

Type

Article

Created At

23 Dec 2024