Background: Numerous studies established a significant positive correlation between HG and the presence of H. pylori.   
Aim: This study aimed to assess the effects of helicobacter pylori infection among pregnant women with hyperemesis gravidarum on pregnancy outcome. 
Patients and Methods: This cross-sectional study was conducted on 180 pregnant females with hyperemesis gravidarum. Women were assigned to one of two groups: Group A: pregnant women with hyperemesis gravidarum, who were tested positive for the presence of H. pylori infection and group B: pregnant women with hyperemesis gravidarum, who were tested negative for the presence of H. pylori infection.
Results: Group A had significantly higher percentage of abortion, past history of HG and family history of HG than group B with statistically significant differences as p<0.05. Group A had significantly lower mean of hemoglobin than group B with statistically significant differences as p<0.001. While group A had higher mean of random blood sugar than group B with statistically significant differences as p=0.014. Women in group B showed significantly higher resolution of HG than group A (p<0.001). Women in group B showed significantly higher resolution of HG and weight gain than group A (p<0.001). Group A had higher incidence of preterm labor and neonates with low birth weight than group B with statistically significant differences.
Conclusion: Although a link between H. pylori and HG has previously been established, this paper makes an important contribution to the literature by confirming this relationship among Egyptian women.