Background: Placenta accreta spectrum (PAS) has serious fetal and maternal outcomes. Short-term morbidities of placenta PAS are well defined, but little is known about long-term outcomes and quality of life (Qol).  
Aim: This study aimed to evaluate the World Health Organization Quality of Life Questionnaire (WHOQOL) in women with PAS.
Methods: This is a cross-sectional study. All women with a confirmed diagnosis of PAS were included. The study was conducted in an outpatient maternal clinic, Assiut University Hospital, Assiut, Egypt, between October 2020 and October 2021. All participants underwent detailed clinical and obstetric evaluation. WHOQOL score was measured in those patients at short and long-term postpartum follow-up.
Results: A total of 80 women were eligible for our study. The mean age of recruited women was 30.86 ± 4.68 years. A total of 38 (47.5%) women developed different forms of complications. Both groups with/without complications showed significant improvement in different domains of the score at the 12th month of follow-up. At baseline, women with complications had significantly lower environment domain. Also, baseline social relationships had a significant positive correlation with the frequency of parity and cesarean section (CS).
Conclusion: Pregnant women complicated by PAS had significant improvement in WHOQOL- domains after 1 year of follow-up. Domains of WHOQOL weren't greatly affected by complications of PAS. Future research at several centers is necessary to confirm these findings.