Pre-eclampsia (PE) is a heterogeneous disease affecting different body systems and often associated by morbimortality. Early PE prediction could reduce this accompanied morbimortality as it will give the chance for proper surveillance and utilization of prophylactic measures. This study was a cross-sectional study done to evaluate platelet indices (PI) as potential predictors for the onset and severity of preeclampsia, and it was conducted at Department of Obstetrics and Gynecology at Mansoura University Hospital from July 2021 to June 2022, on 87 pregnant women divided into 3 groups: (Group I): Healthy normotensive (NT) pregnant females with a gestation period>20 weeks are included as control group, (Group II &III): early and late onset preeclampsia (before and after 34 weeks respectively). The results showed significant difference among the three studied groups in the context of  Platelet crit (PCT). We concluded that PI have been demonstrated as potential markers for PE prediction and could act as diagnostic criteria for PE.