Background: The Protein-Creatinine ratio (P/C Ratio) measurement is an alternative diagnostic method for quantitatively evaluating proteinuria in pre-eclampsia. This study aimed to assess the precision of the protein/creatinine ratio as a diagnostic tool for proteinuria in preeclamptic pregnant patients.  
Methods: A prospective study was conducted at the Obstetrics and Gynecology Department of a private hospital in KSA from July 2021 to January 2023, 100 pregnant women with preeclampsia were included in the study. All patients in the study underwent a history taking, physical examination, routine laboratory investigations, and urine protein/creatinine ratio assessment.  
Results: The findings found substantial positive connections between 24-hour protein, proteinuria, and serum creatinine, as well as strong positive P/C ratio and 24-hour protein correlations. Urine creatinine and P/C ratio were shown to have strong negative correlations. The P/C ratio needs to be less than 0.29 to detect more than 300 mg of protein excretion per 24 hours, detecting 300 mg/24 hours of protein excretion with sensitivity of 95.3% and specificity of 71%.
Conclusion: Random PCR may be employed in urgent situations as a quick, simple, and accurate diagnostic for the detection of substantial proteinuria in hypertensive diseases during pregnancy.