Background: The gold standard for diagnosing intrauterine anomalies is now hysteroscopy. 10–15% of women undergoing subfertility treatment have intrauterine lesions such adhesions, uterine septum polyps, or submucous myomas, which are significantly more accurately detected via hysteroscopy.  
Objectives: Assessment of the value of hysteroscopy in cases with unexplained infertility.
Methodology: This study was conducted in early cancer detection unit, Ain Shams Maternity University Hospital where 75 women with unexplained infertility from 21-35 years were included in the study from Jan 2018 to Feb 2021. All women were subjected to hysteroscopy to diagnose and treat any uterine lesions undetected by the conventional means. Hysteroscopic examination was performed in the proliferative phase of the menstrual cycle.
Results: There was no difference between cases with and without hysteroscopic finding as regard personal and medical characteristics. There was no significant difference between cases with and without hysteroscopic finding as regard occurrence of complications. However, a highly significant difference was found between cases with and without hysteroscopic finding as regard occurrence of pregnancy, as 56% of cases with positive findings got pregnant compared to 2% only of cases without hysteroscopic finding.
Conclusion: So, hysteroscopy (diagnostic, therapeutic) should be performed in women with unexplained infertility.