Background: Surgical site infections (SSI) in cesarean delivery (CD) can delay wound healing, impair cosmetic outcome and increase healthcare costs. Topical antibiotics are sometimes used to reduce microbial contaminant exposure following cesarean section. 
Objective: The current study will investigate the role of subcutaneous Fusidic acid instillation for prophylaxis against surgical site infection in cesarean delivery.
Methods: This is a single blind randomized controlled trial that involved 200 females who underwent elective CD at the department of obstetrics and gynecology of Kasr Alainy medical school, Cairo university between February 2022 and August 2022
Results : Our study showed that with the use of subcutaneous fusidic acid before closing the skin in absorbable stitches, the infection rate was almost 6 times lower as compared to no fusidic acid before closing the skin. 
Conclusion: Therefore, the use of subcutaneous fusidic acid instillation can be safely recommended for the prevention of wound infection (surgical site infection).