Abstract 
A 28 years old primigravida 19 weeks pregnant carrying Diamniotic dichorionic twin pregnancy was suffering from jaundice due to CMV infection and fetal ascites which was successfully managed by IV Ganciclovir. Fetal infection by CMV leading to NIHF could be reversed completely by early detection and proper management using antiviral treatment. Despite the rarity of the cases and the difficulty of confirming the diagnosis, CMV should be considered in the differential diagnosis of NIHF, putting in consideration that early start of treatment will lead to better prognosis.