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286064

Sublingual misoprostol before insertion of levonorgestrel-releasing intrauterine contraceptive device in lactating women following cesarean section

Article

Last updated: 23 Dec 2024

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Abstract

Background: Misoprostol is used for cervical softening before minimally invasive gynecological procedures. We aimed to assess the benefits and drawbacks of using sub-lingual misoprostol before inserting the levonorgestrel-re-leasing intrauterine contraceptive device (LNG-IUCD) in women who have never had a vaginal birth.
Methods: A clinical trial was conducted on 72 recruited women with lactational amenorrhea with no previous vag-inal delivery. They were equally divided into 2 groups; group 1 received sublingual misoprostol   400 mcg 2 hours before Mirena insertion, and group 2 received a placebo 2 hours before the  procedure.  
Results: We observed easy insertion of Mirena IUCD in women of the misoprostol group, but with no significant  difference between both groups. However, the duration of IUCD insertion was significantly  shorter in the misoprostol group compared to the placebo group (5.03 ± 0.74 vs. 5.58 ± 0.94  minutes, P=0.007). The VAS pain score was signifi-cantly decreased  in the misoprostol group (3.33 ± 1.29 vs. 3.97 ± 1.28,  P=0.038) with a higher patient satisfaction score (7.22 ± 1.38 vs. 6.28 ± 1.41, P=0.005). Regarding the side effects, women in the misoprostol group experienced more nausea/vomiting, slight hyperthermia, and  uterine cramps (P= 0.018, 0.011, and 0.173, respectively). 
Conclusion: Sublingual administration of misoprostol be-fore Mirena IUCD insertion could help increase the ease of insertion with a significant decrease in the procedure time. Furthermore, it could improve patient satisfaction and de-crease the pain experience.

DOI

10.21608/egyfs.2023.286064

Keywords

Sublingual misoprostol, Levonorgestrel-releas-ing IUCD, Mirena

Authors

First Name

Hany

Last Name

Saad

MiddleName

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Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

hanysaad25280@gmail.com

City

-

Orcid

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First Name

Hadeer

Last Name

Mashaal

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Elfakhrany

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

1

Related Issue

39711

Issue Date

2023-01-01

Receive Date

2023-02-17

Publish Date

2023-01-01

Page Start

70

Page End

76

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 27_Issue 1_Pages 70-76.pdf

PDF . 2.8MB

Link

https://egyfs.journals.ekb.eg/article_286064.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=286064

Order

286,064

Type

Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Sublingual misoprostol before insertion of levonorgestrel-releasing intrauterine contraceptive device in lactating women following cesarean section

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Type

Article

Created At

23 Dec 2024