Aim:The current study was conducted to evaluate the effectiveness of Calcium,Phosphate,Xylitol and Provitamin D Panthenol containing Fluoride Gel on plaque bacterial count and salivary pH versus Conventional Fluoride Gel in high caries risk adult patients.Methodology:Thirty-two participants were treated without a prior dental prophylaxis.Unstimulated saliva was collected to measure pH using pH meter.Plaque was collected with sterile wooden toothpicks or removed by a dental floss from a single interproximal area and samples were cultured on the same day.After baseline plaque assessment for each participant,gel application procedure was carried out using commercially available fluoride applicator trays.The control group received conventional fluoride gel(colgate gel kam)(0.4% stable stannous fluoride gel). The intervention group received fluoride gel system contains calcium, phosphate, xylitol and provitamin D-panthenol (Fluor protector gel). Streptococcus mutans bacterial count in plaque and salivary pH were evaluated at base line, one week, 6 weeks and after 12 weeks follow up. Results: For interdental plaque bacterial count both gels showed a statistically significant reduction between the baseline and all follow-ups (P<0.001). While There was no statistically significant difference between both groups in bacterial plaque count (p=1). For salivary pH both groups showed a statistically significant increase between the baseline and all follow-ups (P<0.001). While There was no statistically significant difference between both groups (p=0.280). Conclusion: Both fluor protector gel and colgate gel kam resulted in plaque bacterial count reduction and an increase in salivary pH, Re-application of fluoride gel every 3 months is preferred for high caries risk patients for better plaque bacterial control.