Background: This study aimed to compare the effect of Silver diamine fluoride (SDF) and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on the desensitization and remineralization of dentin.
Method: Twenty-eight dentin discs were divided into four groups with seven discs each. In group I, discs were immersed in 17% EDTA for 5 minutes only, while group II, III, and IV were immersed in 17% EDTA for 72 hours. Group III was then treated with SDF (Toothmate, Mansoura, Egypt) and group IV was treated with CPP-ACP (MI Paste Plus, GC, Tokyo, Japan) following the manufacturers' instructions. Finally, all groups were immersed in artificial saliva for 72 hours. The discs were collected and examined under a scanning electron microscope (SEM) to analyse the number of opened dentinal tubules and the percentage of calcium level in each group. Collected data were analyzed using One-way ANOVA and Tukey HSD post hoc tests (p< 0.05).

Results: Statistically significant differences were found between all four groups in terms of the number of opened dentinal tubules and calcium level (p<0.05). Regarding opened dentinal tubules count, the highest mean was found in group II (80.71±9.39), while the lowest mean value was observed in group III (9.14±2.54). For calcium level analysis, the highest mean value was found in group III (35.34±1.37). In contrast, the lowest mean value was observed in group II (14.47±1.26).
Conclusion: SDF had a better effect than CPP-ACP on demineralized dentin surface in terms of desensitization and remineralization.