Background: Nowadays there is a paradigm change in the medical and dental areas due to the exhibition of artificial intelligence (AI) concept. As AI has a prospective influence on the present and upcoming practitioners, understanding its basic conception, the working principle, and its applications as a diagnostic tool in pediatric dentistry is mandatory for its' usage. Objective: The current study aimed to assess knowledge, attitude, and perception regarding the future of AI in Pediatric Dentistry in a group of Egyptian dental students. Subjects and methods: the present study is a descriptive cross-sectional based questionnaire, including 15 questions distributed through Google Forms® to 312 dental students that was carried out among fifth-year dental students in Future University in Egypt (FUE). The questionnaire collected demographic data of participants and assessed their knowledge, attitude, and perception regarding the future of AI in Pediatric Dentistry. Results: Responses obtained were statistically analyzed. Conclusions: Based on the outcomes of the study, it is recommended that additional investigations and insights into AI should be conveyed through curricular courses, lectures and webinars to discover and expand the awareness about this interesting concept.