Aim: Assess milling versus 3D printing construction technique and different pH media effect on the interim restorations surface roughness and color stability. Materials and methods: Fourteen 3D-printed resin and 14 milled PMMA discs were divided into two groups (n=7) based on pH media (Coffee and Fanta) for immersion. At two-time immersion intervals (1 and 7 days), the surface roughness using a non-contact profilometer and color stability using a spectrophotometer were tested. Results: Milled groups showed higher surface roughness at the baseline in both immersions and after 7 days immersion in coffee (0.2908±0.0015). After 7 days in Fanta, 3D printed group showed higher surface roughness (0.2921±0.0013). Considering color stability, after 1- and 7-days immersion, 3D printed group showed a higher color change (ΔE) in coffee (6.15±1.94) than milled group (3.97±1.24). Milled group showed a higher ΔE significance in Fanta (6.17±2.48) than 3D printed group (3.35±1.38). Conclusion: The surface roughness and color stability of interim restorations were affected by the material, construction technique, and different pH beverage consumption. After seven days, Coffee increased the milled interim surface roughness, whereas Fanta increased it in 3D printed restorations. Coffee immersion induced more color change in the 3D printed interim restorations while Fanta immersion induced more color change in the milled interim restorations after one and seven days.