Background and objectives: Ameloblastomas and odontogenic keratocysts are benign odontogenic lesions of an epithelial origin that displayed behavior of local destruction and high recurrence. Podoplanin is designated as an endothelial lymphatic marker and it is linked to invasion and cell motility; its role together with β- catenin still not entirely elucidated in both odontogenic lesions. Materials and methods: Both Podoplanin and β- catenin were immunohistochemically inspected in archival paraffin blocks of ameloblastoma and odontogenic keratocyst. Results: Podoplanin and β- catenin are strongly expressed in all layers of follicular ameloblastoma; however, in odontogenic keratocysts; podoplanin is only expressed in basal cell layer. Conclusions: Podoplanin is expressed in ameloblast like cells in ameloblastomas and basal cells of odontogenic keratocysts. It might be associated with cell migration and local invasiveness of both lesions. Besides; both podoplanin and ꞵ-catenin varied expression in ameloblastoma subtypes and odontogenic keratocyst might be useful in odontogenic lesions diagnosis.