Post endodontic pain is any degree of discomfort that develops after the start of root canal treatment. Post endodontic pain may be attributed to the employment of different types of movement patterns, the size of the apical preparation, the number of appointments and obturation operations, and the pre-operative conditions. The aim of the research is to assess the degree of discomfort encountered by patients following endodontic operations utilizing two distinct systems: the S-ONE Pro Single Niti Reciprocation file and the One Curve Endodontic file systems. Pain degree was measured using a Visual Analog scale to document pain intensity six hours pretreatment. Patients were allocated to two test groups. A group had endodontic treatment using the S-one pro reciprocating file. The second group was subjected to treatment using the One Curve Endodontic file. After receiving treatment, patients document their pain level after 6, 24, 48 ,72, and 168 hours. Pain-relieving medication, ibuprofen 600 mg, was given to alleviate severe pain. No significant statistical difference was observed between groups as regarding postoperative pain degree, and painkiller consumption. However, S-ONE Pro Single Niti Reciprocation file was found to be related with lower postoperative pain compared to the complete sequence continuous rotating file. Nevertheless, both groups observed a statistically significant reduction in discomfort over time.