Introduction: Cisplatin is a common anticancer chemotherapeutic drug that has several side effects, which necessitated the introduction of palliative materials to minimize these side effects. The natural oils extracted from herbal plants revealed promising effects in this regard.

Aim of the work: To evaluate the potential protective properties of sesame and moringa Oils to minimize the effects of cisplatin on the parotid gland of albino rats.

Materials & Methods: Twenty adult male albino rats were equally divided into 4 groups: Group A: control, with no treatment; group B: received a single dose of intraperitoneal injection of cisplatin (5 mg/kg body weight). Group C and D received oral sesame and moringa seed oils, respectively (5mg/kg/day for 10 days), in addition to the same cisplatin dose as group B. The parotid glands were examined via routine histological staining and immunohistochemical staining for Proliferating cell nuclear antigen (PCNA).

Results: Cisplatin group revealed degenerative changes and vacuolations in the acini, distortion in the ducts, congestion in the blood vessels, and decrease in PCNA expression compared to control group. There were enhanced histological features in the sesame and moringa treated rats with non-significant change in PCNA expression compared to cisplatin group.

Conclusion: Cisplatin deteriorating effects on the parotid glands are potentially protected by the co-administration of either sesame oil or moringa seed oil.