Abstract

Objectives: identify the diagnostic accuracy of tissue Cystatin (SA) in diagnosis of oral lichen planus
Methodology: The present study included 58 Patients divided into 2 groups, group I: 29 healthy control patients and group II: 29 Patients clinically diagnosed with oral lichen planus. Tissue biopsy was taken and the production of tissue cystatin SA was determined by enzyme immunoassay. We described and compared the protein profiles (Cystatin SA) in the tissues, from patients who presented with oral lichen planus and from healthy controls. Data were presented as mean and standard deviation values and were analyzed using independent t-test. Correlations were analyzed using Spearman's rank order correlation coefficient.
Results: The Oral Lichen Planus group had a significantly higher Cystatin-SA level than the control group (p<0.001). The mean value of the cystatin SA in the Oral Lichen Planus group was 19.68±3.69, whereas the mean value of the cystatin SA in the control group was 7.22±1.6, suggesting a role for the cystatin SA in the diagnosi of Oral Lichen Planus.
Conclusions: Cystatin-SA expression in Oral Lichen Planus patients was more outstanding than in healthy control subjects.


Key words: Biopsy, autoimmune disease, immunoassay