Aim: The purpose of the current study was to radiographically evaluate the effect of platelet rich fibrin (a source of growth factors) versus collagen on the osteogenic potential of bone marrow aspirate concentrate loaded on bovine graft in sinus floor augmentation. Patients& methods: Lateral sinus floor augmentation was performed for twelve eligible patients utilizing bovine bone graft loaded with bone marrow aspirate concentrate. The lateral osteotomy window was covered with platelet rich fibrin membrane in the study group (6 sinuses) in comparison to collagen membrane for the control group (6 sinuses). The newly formed bone height and density were measured immediate (one week) and at four months follow up period on CBCT. Results: The mean age of the patients in the study group was (46.83±5.64) years and in the control group it was (44.03±7.60) years. The control group had significantly higher density than the study group (p<0.05). However, there was no significant difference between the tested groups regarding bone height (p=0.205). Conclusions: Collagen membrane utilization has yielded higher bone density compared to the PRF membrane in sinus floor augmentation. No significant difference among the studied groups was observed in the bone height.