Aim: To assess the potential impacts of propolis and mucoadhesive mycophenolate mofetil (MMF) on oral lichen planus.
Methodology: The research was performed on 30 individuals suffering from atrophic-erosive oral lichen-planus. And they were allocated into three groups; Group Ӏ: were managed with propolis 5% gel, Group ӀӀ: were managed with Mycophenolate mofetil (MMF) 2% mucoadhesive and Group ӀӀӀ (control group): were managed with triamcinolone acetonide 0.1%. The clinical progress was evaluated utilizing the Visual Analog Scale (VAS) for pain intensity and MOMI scale. The clinical parameters were recorded at the baseline and then every two weeks for two months.
Results: A substantial enhancement existed in all clinical results throughout the follow-up period when compared to the baseline (P <0.05). There was non-significant variation among the studies groups at the end of the eight's week regarding VAS and MOMI scale (P˃0.05).
Conclusions: Propolis and MMF might be utilized as alternative treatment for the management of oral lichen-planus.