Abstract:
Objective: The objective of this clinical trial was to compare changes in IL-34 level in Gingival cervicular fluid (GCF) before and after nonsurgical periodontal therapy (NSPT) in individuals with biofilm-induced gingivitis in relation to periodontal clinical signs.
Methods and materials: Twenty patients, both genders, aged 20 to 50, have been diagnosed with biofilm-induced gingivitis. The following parameters were considered clinically at baseline and three months after NSPT: probing depth (PD), gingival index (GI), and plaque index (PI).
Results: 3 months postoperatively, a substantial reduction in the level of IL-34 in GCF was detected along with better improvement in all clinical parameters compared to preoperative level in addition to positive correlation among changes in the level of GCF IL-34 along with changes in all clinical parameters.
Conclusion: IL-34 can be regarded as one of the pro-inflammatory markers of periodontal disease and may be investigated in the future as a potential target for periodontal disease therapy.