Aim: The aim of this study is to evaluate the cleaning efficacy between Manual K-Files and Two Pediatric Rotary Files. Methodology: An in vitr- study was conducted on thirty extracted primary molar teeth. Teeth were randomly divided into three groups; where Group I: Manual K-files, Group (II): Kedo-S Square rotary files and Group (III): Kedo S-SG Blue rotary files. Teeth were injected with india ink by insulin syringe then canals were prepared by the files. After instrumentation teeth were decalcified, dehydrated, and cleared till teeth become transparent for scoring and evaluation of amount of ink removed. Results: There was a significant difference between Manual group and the two rotary groups (p value <0.001) with mean value (2.67±0.48), (1.47±0.89), and (1.47±0.93), for manual, Kedo S-Square and Kedo S-SG Blue respectively. Conclusion: Pediatric rotary files showed better cleaning efficacy compared to manual K-files and they can be considered as alternative to hand instrumentation.