purpose: to evaluate revascularization induced maturogenesis of non-vital immature teeth using Platelets rich plasma compared to blood clot as scaffolds with two different medications: modified triple antibiotic paste and calcium hydroxide mixed with chlorhexidine. Materials and Methods: 32 patients requiring endodontic therapy of maxillary centrals were selected. Patients were divided into four equal groups (n=8); Group I: Blood clot scaffold/mTAP intra canal medication ,Group II: PRP scaffold/mTAP intra canal medication ,Group III: Blood clot scaffold/Ca(OH)2 mixed with CHX intra canal medication ,Group IV: PRP scaffold/Ca(OH)2 mixed with CHX intra canal medication. Patients were evaluated clinically and radiographically for any change in apical foramen diameter, root length and root canal diameter. Radiographic digital examination was done immediately postoperative and at 3,6,9 and 12months of follow-up. Results: Clinically, all patients were completely asymptomatic through out the study. Radiographically, concerning percentage of root length increase, PRP produced superior results with statistically significant difference compared to blood clot as a scaffold while mTAP showed significantly better results compared to Ca(OH)2 mixed with CHX as intracanal medication. Concerning percentage of canal diameter decrease and apical foramen diameter decrease, using PRP scaffold with mTAP medication produced superior results with statistically significant difference when compared to blood clot scaffold with a mix of Ca(OH)2 and CHX medication respectively. Conclusions: PRP is better than Blood clot as a scaffold and mTAP is better than Ca(OH)2 mixed with CHX as an intracanal medication when they are used during revascularization of immature teeth.