Aim: To assess fracture strength of CAD-CAM fabricated molars endocrowns restoring endodontically treated molars using different types of litium disilicate blocks. Materials & methods: A maxillary first molar tooth was prepared to receive an all-ceramic endocrown, scanned with primescan intraoral scanner. A STL file was transferred to Formlabs 3D-printer to print twenty-eight resin dies. One die was scanned with primescan and twenty-eight lithium disilicate endocrowns were milled with Cerec MC X5 milling machine. Endocrowns were grouped into four groups (n=7); Group EC (IPS. Emax CAD), group CT (Cerec Tessera), group IL (GC Initial LiSi CAD) and group AM (Amber Mill). Endocrowns were bonded using Panavia F2.0 adhesive resin cement. Endocrowns were tested for fracture strength using a universal testing machine at a crosshead speed of 1 mm/min. Data were analyzed by one way ANOVA and Post Hoc Tests at p  0.05. Results: There was a significant statistical difference between mean fracture strength of all groups where group CT showed the highest mean fracture strength followed by groups EC and AM then Group IL. Conclusions: Tested lithium disilicate endocrowns showed different fracture strength means but all were within the clinically acceptable range. Keywords: Lithium disilicate, Endocrowns, Fracture strength, Bonding, CAD/CAM.