Cisplatin (CP) is an antineoplastic agent that is most widely used in the chemotherapy of many types of tumors. Moringa oleifera oil (MO) and Sesame oil (SO) seeds are promising resources due to their content of monounsaturated fatty acids, sterols, tocopherols, and proteins rich in sulfated amino acids. This research aimed to compare the effect of MO and SO against damage induced by CP in submandibular glands of albino rats. Forty-five rats were randomized into 4 groups; group I: the control group, group II: was given a single intraperitoneal injection of CP (5 mg/kg), group III: was given MO (5mg/kg/day) orally, group IV: was given SO (5mg/kg/day) orally. Histopathological alterations such as cytoplasmic vacuolation, irregular dark shrunken nuclei, loss of normal acinar architecture, irregular and distorted ducts with focal loss of lining epithelium and basement membrane, and congested blood vessels were seen in the CP group. A significant decrement in PCNA and PAS expression and a significant increment in α-SMA and Caspase-3 expression were demonstrated in the CP group. Amelioration of thesefindings was noticed in MO and SO groups. This study wrote down that both MO and SO ameliorated the damage caused by cisplatin with slight superiority over SO.