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292701

Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized contr

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Oral Medicine, Periodontology and Diagnosis

Abstract

Abstract:
Objectives: The study aims to evaluate the effect topical tacrolimus as adjunctive to systemic corticosteroids in treatment of mucous membrane pemphigoid.
Material & Methods: The present study was conducted on 76 patients with severe mucous membrane pemphigoid according to chan et al classification. Patients were allocated (1:1) to a group. Group A (control group) patients treated with 40 mg systemic corticosteroids alone and group B (Study group) patients were treated with 40 mg systemic corticosteroids and topical tacrolimus as adjunctive to corticosteroids. Total ulcers score (site, activity, and pain score) was recorded in both groups on weekly basis till the full recovery of oral, oropharyngeal and nasal lesions.
Results: Both treatment regimen had shown a significant improvement in total ulcer scores with (P<0.001) of the oral and nasal lesion scores from the beginning of the study to its end, but the study group (combination of corticosteroids and tacrolimus) revealed significant decrease (P<0.001) compared to the study (corticosteroid alone) group.
Conclusion: The use of topical tacrolimus as adjunctive to systemic corticosteroids could improve healing and total ulcer score in severe cases of mucous membrane pemphigoid than solo treatment with systemic corticosteroids

DOI

10.21608/edj.2023.194457.2449

Keywords

Mucous membrane pemphigoid, systemic corticosteroids, Topical tacrolimus, Total ulcers score

Authors

First Name

Yasmine

Last Name

Hamed

MiddleName

-

Affiliation

Lecturer of Oral Medicine and Diagnosis, Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral And Dental Surgery, Modern University For Technology & Information

Email

yasmine.gamil@hotmail.com

City

-

Orcid

0000-0003-3268-5043

First Name

wesam

Last Name

Abd elmoniem

MiddleName

-

Affiliation

Professor of Oral Medicine, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Surgery, Cairo University

Email

wesammhs@yahoo.com

City

-

Orcid

0000-0001-8293-9967

First Name

Mahitab

Last Name

Elsayed

MiddleName

-

Affiliation

Lecturer of Clinical Pharmacy, Clinical Pharmacy Department, Faculty of Pharmacy, Modern University For Technology & Information

Email

mahitabmostafaelsayed@gmail.com

City

-

Orcid

0000-0003-1251-0537

First Name

Aya

Last Name

Essawy

MiddleName

-

Affiliation

Lecturer of Clinical Pharmacy, Clinical Pharmacy Department, Faculty of Pharmacy, Modern University For Technology & Information

Email

aya.essawy@pharm.mti.edu.eg

City

-

Orcid

0000-0002-5515-8230

First Name

Mohamed

Last Name

Hamed

MiddleName

-

Affiliation

Associate Professor of Otolaryngology, Faculty of Medicine, Helwan University

Email

gamilio1976@gmail.com

City

-

Orcid

0000-0002-3428-3876

First Name

rawda

Last Name

elsherif

MiddleName

-

Affiliation

Lecturer of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral and Dental Surgery, Misr University For Science and Technology.

Email

radwa.mohamed@must.edu.eg

City

-

Orcid

0000-0002-0128-6042

Volume

69

Article Issue

2

Related Issue

40503

Issue Date

2023-04-01

Receive Date

2023-02-22

Publish Date

2023-04-01

Page Start

1,153

Page End

1,160

Print ISSN

0070-9484

Online ISSN

2090-2360

Article File

EDJ_Volume 69_Issue 2_Pages 1153-1160.pdf

PDF . 737.4kB

Link

https://edj.journals.ekb.eg/article_292701.html

Detail API

https://edj.journals.ekb.eg/service?article_code=292701

Order

16

Type

Original Article

Type Code

254

Publication Type

Journal

Publication Title

Egyptian Dental Journal

Publication Link

https://edj.journals.ekb.eg/

MainTitle

Topical administration of tacrolimus and systemic corticosteroids in treatment of oral and nasal mucous membrane pemphigoid in a sample of Egyptian population: A randomized control Clinical trial

Details

Type

Article

Created At

23 Dec 2024