Background: Studying of possible prognostic markers for squamous cell carcinoma (SCC) is of great benefit that can alter treatment and follow-up protocols proposed for different grades of the lesion. As a newly identified tumor suppressor gene, SMARCB1 levels in different histological grades of SCC can be used as a predictor of prognosis. Similarly, levels of CD3 positive tumor infiltrating lymphocytes (TILs) in SCC can be used to distinguish tumor grades. Aim: To assess the levels of SMARCB1 and CD3 in different grades of SCC, and correlate between their expression and tumor prognosis based on the histological grade. Material & methods: Thirty three formalin fixed paraffin-embedded archival blocks of oral squamous cell carcinoma (OSCC) were used in this study; eleven cases from each group were tested (group 1 well-differentiated, group 2 moderately-differentiated and group 3 poorly-differentiated). Immunohistochemical study was performed on the specimens to evaluate the expression of SMARCB1 and CD3 positive tumor infiltrating lymphocytes (TILs). The area fraction of both genes' expression was calculated. The data was analyzed and expressed statistically. Results: Group1 showed high CD3 gene expression and low SMARCB1 gene expression. Group2 to showed almost similar gene expression results as group 1. Group3 showed marked decrease in CD3 gene expression and high SMARCB1 gene expression. Conclusion: Our findings revealed that high expression values of SMARCB1 may be used as an evidence for poor prognosis while presence of high numbers of CD3+ T cells is associated with good prognosis and increased survival in oral squamous cell carcinoma.