Aim: To evaluate the efficiency of Platelet Rich Plasma vs. Platelet Rich Fibrin on overall leveling and alignment time of mandibular anterior crowding.

Subjects and methods: Thirty-six females (18-25 years) with mandibular anterior crowding were randomly allocated into PRP, PRF, or control groups. The first molars on the right and left sides of the mandible were banded or bonded with Roth prescription tube. Mandibular teeth Second premolar to the second premolar were bonded using 0.022-inch pre-adjusted edgewise mini diamond brackets with Roth prescription. Immediately after bonding of the brackets, the initial wire used, the wire sequence was 0.014 Cu-Ni followed by 0.016 Cu-Ni and finally 16x22 NiTi. Our cut-off was 17x25 Stainless Steel wire. In PRP or PRF group, the patients were injected into the mandibular anterior segment on the first day of fixed appliance insertion. Over the period of seven days following the initial archwire insertion, visual analogue scale questionnaires were completed by each patient. The irregularity index was monitored using digital models.

Results: The average alignment time was considerably shorter in the PRP and PRF groups compared to the control group (60±15, 64.29±26.99, and 126.43±51.86 days respectively). The PRP and PRF group displayed a significantly higher mean alignment improvement percentage as well as lower pain scores compared to the control group.

Conclusions: PRP and PRF have the ability to accelerate the alignment of the anterior segment and decrease the discomfort produced by the first insertion of the arch wires.