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Salivary Levels of Soluble Fas in Oral Lichen Planus Patients Before and After Treatment with Topical Corticosteroids

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Oral Medicine, Periodontology and Diagnosis

Abstract

Purpose: Oral Lichen planus (OLP) is a chronic mucocutaneous disorder. Some factors associated in induction of apoptosis in OLP include Fas/FasL pathway. The aim of this investigation was to detect the salivary levels of apoptotic related marker soluble Fas (sFas) in OLP patients.
Methods: 30 individuals were divided into 2 groups: 15 patients suffering from OLP and 15 healthy individuals as controls. Clinical score for OLP lesions and pain assessment at exacerbation was collected. Saliva samples were collected twice from the OLP group at baseline and after topical corticosteroid treatment and once from control group.
Results: The mean salivary levels of sFas were significantly higher in OLP group at baseline than that of control group. After treatment sFas levels, pain and clinical scores decreased significantly in OLP group when compared to baseline.
Conclusion: sFas levels in saliva were higher in patients with OLP when compared to controls and decreased significantly after treatment which may emphasize its role in the pathogenesis of the disease.

DOI

10.21608/edj.2022.175893.2355

Keywords

Fas/FasL pathway, pathogenesis, apoptosis, mRNA, Pain

Authors

First Name

Sarah

Last Name

Moussa

MiddleName

-

Affiliation

Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt

Email

sara.gamal@fue.edu.eg

City

Cairo

Orcid

0000-0001-8455-7938

First Name

Sherif

Last Name

Amer

MiddleName

-

Affiliation

Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt

Email

sherif.abdelrahman@fue.edu.eg

City

-

Orcid

0000-0002-9256-2961

First Name

Noha

Last Name

Nagy

MiddleName

-

Affiliation

Assistant Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt.

Email

noha.ahmed@fue.edu.eg

City

New Cairo

Orcid

0000-0001-5246-2301

First Name

Sara

Last Name

Galala

MiddleName

-

Affiliation

Assistant Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt.

Email

sara.abdelhalim@fue.edu.eg

City

New Cairo

Orcid

0000-0001-6672-4050

First Name

Mai

Last Name

Elgendi

MiddleName

-

Affiliation

Assistant Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt.

Email

mai.mohamed@fue.edu.eg

City

New Cairo

Orcid

0000-0002-5832-5305

First Name

Shahira

Last Name

El Ashiry

MiddleName

-

Affiliation

Professor of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt.

Email

shahira.elashiry@fue.edu.eg

City

New Cairo

Orcid

0000-0002-6461-3020

Volume

69

Article Issue

1

Related Issue

38925

Issue Date

2023-01-01

Receive Date

2022-11-23

Publish Date

2023-01-01

Page Start

439

Page End

446

Print ISSN

0070-9484

Online ISSN

2090-2360

Article File

EDJ_Volume 69_Issue 1_Pages 439-446.pdf

PDF . 548.6kB

Link

https://edj.journals.ekb.eg/article_281472.html

Detail API

https://edj.journals.ekb.eg/service?article_code=281472

Order

25

Type

Original Article

Type Code

254

Publication Type

Journal

Publication Title

Egyptian Dental Journal

Publication Link

https://edj.journals.ekb.eg/

MainTitle

Salivary Levels of Soluble Fas in Oral Lichen Planus Patients Before and After Treatment with Topical Corticosteroids

Details

Type

Article

Created At

23 Dec 2024