Beta
354539

The relation of HbA1c levels with mortality rates in hospitalized COVID-19 diabetic patients: A Retrospective Cohort Study conducted in Egypt

Article

Last updated: 23 Dec 2024

Subjects

-

Tags

Surveillance and monitoring of diseases

Abstract

Background: Identifying mortality factors in type 2 diabetic patients with COVID-19 is crucial. Objectives: To investigate the association between HbA1c levels and mortality rates in hospitalized COVID-19 diabetic patients. Methods: A 5-month retrospective cohort study at Al-Agouza hospital in Egypt included 167 adult COVID-19 diabetic patients. Patients were categorized by HbA1c levels at admission(≤ 7%, 7.1% to 8.9%, and ≥ 9%). Hospital mortality was the primary outcome. Results: The mean age was 66±10.2 years and the majority (56.3%) of patients were males. Out of 167 patients, 51 (30.5%) had HbA1c ≤ 7%, 77 (46.1%) had HbA1c between 7.1% and 8.9%, and 39 (23.4%) had HbA1c ≥ 9%.The average hospital stay was 12 days. Approximately 35.3% of patients required ICU admission and 35.9% died. The lowest HbA1c levels (≤ 7%) were associated with highest mortality rates (43.1%), however the difference did reach not statistical significance (p=0.385). The multivariate Cox regression analysis demonstrated a significant association between age ≥ 70 years (HR 1.85, 95% CI 1.04 -3.28), severe and critically ill cases (HR 9.88, 95% CI 1.19-82.18), ICU admission (HR 7.66, 95% CI 2.94-19.97), and the administration of insulin sliding scale as hospital glycemic management medication (HR 0.45, 95% CI 0.21-0.96) with mortality in COVID-19 diabetic patients. Conclusions: This study challenges the conventional belief regarding the association between HbA1c levels and mortality in COVID-19 diabetic patients. Nevertheless, age, COVID severity, ICU admission, and the use of insulin sliding scale emerged as significant risk factors for mortality in this population.

DOI

10.21608/ejcm.2024.269951.1283

Keywords

Hospitalized COVID-19 patients, diabetes, HbA1c level, mortality, risk factors

Authors

First Name

Sonia

Last Name

Saleh

MiddleName

S.

Affiliation

Department of Clinical Research, Al-Agouza Hospital, MoHP, Giza, Egypt

Email

drsoniajes@gmail.com

City

Al-Agouza

Orcid

0000-0001-5769-2624

First Name

Mohamed

Last Name

Kabil

MiddleName

Solyman

Affiliation

Department of Clinical Research, Al-Agouza Hospital, MoHP, Giza, Egypt

Email

drmsolyman@gmail.com

City

Al-Agouza

Orcid

0000-0003-2172-2216

First Name

Asia

Last Name

Toukhy

MiddleName

-

Affiliation

Department of Clinical Pharmacy and Research, Al Haram Hospital, MoHP, Giza, Egypt

Email

asia_said@yahoo.com

City

Al-Haram

Orcid

0000-0002-5411-7517

First Name

Amira

Last Name

Khtab

MiddleName

M.

Affiliation

Department of Clinical Research, Al-Agouza Hospital, MoHP, Giza, Egypt

Email

amira.khtab@yahoo.com

City

Al-Agouza

Orcid

0000-0002-8744-5007

First Name

Zinab

Last Name

Emam

MiddleName

M.

Affiliation

Department of Clinical Research, Al-Agouza Hospital, MoHP, Giza, Egypt

Email

emamzinab1@gmail.com

City

Al-Agouza

Orcid

0000-0001-7034-5651

First Name

Manar

Last Name

Ellaban

MiddleName

M.

Affiliation

Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

manarellaban@med.asu.edu.eg

City

-

Orcid

0000-0001-5612-5513

Volume

42

Article Issue

4

Related Issue

51111

Issue Date

2024-10-01

Receive Date

2024-02-14

Publish Date

2024-10-01

Page Start

209

Page End

217

Print ISSN

1110-1865

Online ISSN

2090-2611

Link

https://ejcm.journals.ekb.eg/article_354539.html

Detail API

https://ejcm.journals.ekb.eg/service?article_code=354539

Order

1

Type

Original Article

Type Code

234

Publication Type

Journal

Publication Title

The Egyptian Journal of Community Medicine

Publication Link

https://ejcm.journals.ekb.eg/

MainTitle

The relation of HbA1c levels with mortality rates in hospitalized COVID-19 diabetic patients: A Retrospective Cohort Study conducted in Egypt

Details

Type

Article

Created At

23 Dec 2024