Background: Understanding student's perspectives about the COVID19 vaccine is the back bone for mass immunization to achieve the ultimate goal of herd immunity. Objectives: To assess vaccination status, motives for acceptance and barriers of COVID19 vaccines hesitancy among Tanta university students. Methods: A web-based cross sectional study was carried out among Tanta university students in their final graduation years, Egypt. A convenience sampling of 785 participants successfully completed the survey during the period from May 2021 to June 2021.Results: Only 11.7% were already vaccinated, 27.6% intended to be vaccinated and more than half of the students were hesitant and refused to be vaccinated. The majority of the participant students were knowledgeable regarding the COVID19 vaccine with statistically significant association with the students' vaccination status and the social media was the commonest source of their knowledge. Attitude among vaccinated was significantly more positive than refused students (P=.000). The main barriers were students, concerns regarding efficacy, potential adverse effects and safety. The motives were to protect themselves against COVID19, increased morbidity and mortality and no serious side effects of vaccine. Conclusion: More than half of the students were hesitant and refused to be vaccinated and the main barriers of COIVD19 vaccine were concerns regarding efficacy, potential adverse effects and safety. Meanwhile small percent of them were already vaccinated reporting their main motives; to protect themselves against COVID 19 infection, increased morbidity and mortality and the vaccine has no serious side effects.