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The Possible Protective Role of Ginger in Gamma RadiationInduced Jejunal Enteropathy in Adult Male Rats. A Light and Electron microscopic study

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Last updated: 01 Jan 2025

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Abstract

Background: The intestine is one of the most sensitive organs affected by radiation toxicity, that is why mortality due to radiation enterocolitis stays a challenge. Recent studies had stated that ginger might possess, anti-inflammatory, and antioxidant properties. The study aimed to explore the possible role of ginger as a protective and as a therapeutic agent on the gamma irradiation-induced enteropathy.
Material and Methods: Thirty six adult male albino rats were used in this study. The animals were divided randomly into three groups: group I, control, and group II; (gamma irradiated) each rat was exposed to single exposure of 0.739 (11Gray/min) gamma radiation, group III; irradiated and given ginger extract, it was further subdivided into two subgroups each of them was irradiated as in group II and given ginger extract orally once daily in a dose of 120mg/kg. Subgroup IIIa: received ginger extract seven days before radiation while subgroup III b: received ginger extract fourteen days before and after radiation. Jejunal specimens were collected from sacrificed animals and examined by light and scanning electron microscopes. Morphometric study and statistical analysis were done.
Results: Group II as compared to control showed distortion and fusion of some villi. While the crypts showed focal proliferation of its lining cells and invasion with inflammatory cells. Moreover, subgroup IIIa showed focal disruption of the crypts' wall. Significant decrease in mean number of goblet cells and significant increase in collagen fibers mean percentage area were noticed in group II compared to the control. However, subgroup IIIb showed restoration of most of the structure of the jejunal mucosa to become comparably similar to control.
Conclusion: Ginger seemed to be a promising agent for amelioration of intestinal injury induced by radiation.

DOI

10.21608/ejana.2020.21544.1059

Keywords

electron microscopy, Ginger, Jejunum, Radiation, Rats

Authors

First Name

youssef

Last Name

shoukry

MiddleName

-

Affiliation

department of anatomy , faculty of medicine , ain shams university

Email

dr_yosef@hotmail.com

City

-

Orcid

-

First Name

mona

Last Name

raafat

MiddleName

-

Affiliation

department of histology, faculty of medicine , ain shams university, cairo egypt

Email

raafat.mona@gmail.com

City

-

Orcid

-

Volume

43

Article Issue

2

Related Issue

47246

Issue Date

2024-07-01

Receive Date

2019-12-26

Publish Date

2024-04-01

Page Start

293

Page End

314

Print ISSN

1110-2144

Online ISSN

2090-259X

Article File

EJANA_Volume 43_Issue 2_Pages 293-314.pdf

PDF . 5.5MB

Link

https://ejana.journals.ekb.eg/article_169094.html

Detail API

https://ejana.journals.ekb.eg/service?article_code=169094

Order

26

Type

Original Article

Type Code

231

Publication Type

Journal

Publication Title

The Egyptian Journal of Anatomy

Publication Link

https://ejana.journals.ekb.eg/

MainTitle

The Possible Protective Role of Ginger in Gamma RadiationInduced Jejunal Enteropathy in Adult Male Rats. A Light and Electron microscopic study

Details

Type

Article

Created At

23 Dec 2024