The main objective of our study was to highlight the Blida region population knowledge status about rodent zoonosis, mainly leptospirosis. Data were collected through printed questionnaires applied to a sample of 252 interviewees. The data were entered and coded into tables in Microsoft Excel 2013 and then transferred into the R program for advanced analysis, frequencies were also calculated. The result showed that 91.3% of the respondents confirmed the transmission of the diseases from rodents to humans, however the knowledge about the main risk factors of transmission was insufficient; 38.5% of them stated that contamination occurs through rodent's bite, while, only 6.35% of the respondents cited contamination through contaminated food and 0.4 % of them cited contamination through sewage water. Plague was the most mentioned (23.01%) zoonosis. Some of the interviewees cited respectively, Malaria and Cholera (0.4%, 1.98%); however, these diseases are not associated with rodents. Regarding prophylaxis; 32.9% declared that cleaning and hygiene are necessary to avoid rodent's zoonosis transmission. Concerning leptospirosis, only 14.7% Heard or knew about the disease with urine as a principal factor of transmission cited by just 4.37% and jaundice as symptom by only 2% of the participants. Our study indicates the potential knowledge of the population of Blida about rodent zoonosis and its spread, which needs to be increased.