The purpose of this study was to assess the hepatoprotective effect of Salvia officinalis (Sage) oil against paracetamol-induced hepatotoxicity in broilers. Forty eight healthy, one-day-old Cobb chicks were divided into 4 groups, (12 chicks each): The first group (G1) was given a basal diet for 21 days, the second group (G2) started receiving paracetamol on the 15^th day until the experiment ended, the third group (G3) received S. officinalis oil at 20 ml /Kg of diet for two weeks, then paracetamol for one week, and the fourth group (G4) received paracetamol for one week then S. officinalis oil for two weeks. Blood, serum, and liver samples were collected from each group at the end of the trial for hematological, biochemical, and histopathological assessment. After feeding S. officinalis oil to broilers that had overdosed on paracetamol, the level of hematological parameters (lymphocyte percentage, monocyte percentage, HCT percentage, WBC percentage, RBC count, and Hb content), total protein, and albumin was significantly increased, and the activities of ALT, AST, and ALP were decreased in comparison to the paracetamol group. Moreover, the S. officinalis oil increased the activities of antioxidant enzymes, lowered the amount of reduced glutathione, and decreased the concentration of malondialdehyde. Furthermore, after treatment, a notable decrease in the mRNA expression of TLR4 and lL-1β was seen in hepatic tissues of G3 and G4. In conclusion, S. officinalis oil reduces oxidative stress and inflammation, which lessens the hepatic damage produced by paracetamol in broilers. Future studies are advised to evaluate the effects of S. officinalis components independently.