Background: Nanoparticles (NPs) are minute objects having a diameter ranging from 1 to 100 nm. They can be categorized into several classes according to their shapes, sizes, chemical, and physical properties.  NPs used in numerous fields of biology and medicine as tissue engineering, drug delivery, regenerative medicine, furthermore as antimicrobial agents and for detection of biomolecules. To confirm the efficacy and stability of each nanomaterial it requires informational data about physico-chemical properties. Research on nanoparticles has been increased in the last recent years due to its medical meliorative effect against different pathological and metabolic disorders. The field of bionanotechnology has synchronized with novel regenerative strategies. The high demand for providing suitable cure for diabetes increases the attention toward using various nanoparticles in treatment of diabetes and its complications. Aim: Our goal is to collect information regarding various nanoparticles showing anti-diabetic activity. Methods: We gathered detailed overview from recent research via different databases (PubMed, Taylors, Google Scholar, Elsevier, Egyptian Knowledge Bank, ‎ Springer Nature, Empase, ProQuest), as we focused on the antidiabetic NP papers throughout the Current millennium with special reference to their therapeutic results. Then the collected data were summarised in tables and analysed. And all figures were designed by us through Photoshop and PowerPoint. Results: In this review, we focused on the most common nanoparticles approaches for treatment of‎ diabetic hepatopathy like; curcumin, gold (Au-NPs), silver (Ag-NPs), selenium (Se-NPs), zinc oxide (ZnO-NPs), nano-tyrosol, nano-cinnamon, nano-Stevia, as well as Polydatin loaded chitosan nanoparticles. We also summarize the results of the experiments after receiving nanomaterials through blood glucose level (BGL), insulin level, liver function enzymes (ALT,  AST, and ALP), lipid profile (TG and TC), and gene expression of both (SOD2 and GPx4). Conclusion: The pharmacological and physiotherapy effects of different nanoparticles on diabetes mellitus considered as a very common physiological syndrome which having huge regenerative influence when comparing with other traditional ‎approach for treatment of diabetic hepatopathy.‎