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386233

Assessment of Toxicological Effect of Lactuca serriola L. in Sprague-Dawley Rat

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Pharmacology & Toxicology

Abstract

This study aimed to assess the toxicity level of the alcoholic extract of Lactuca serriole. L. A total of thirty mature male rats were used. The animals were categorized into five distinct groups: Group 1, referred to as the control negative group, did not receive any treatment. Groups 2, 3, 4, and 5, known as the treatment groups, were given different dosages of Lactuca extract through gavage. The dosages administered were 100, 200, 400, and 800 mg/kg/bw, respectively. This treatment was carried out for 14 days. Cardiac blood samples were collected, followed by biochemical testing. Tissue sections from the kidney, liver, and spleen were prepared for H&E staining. There was no notable disparity in body weight between the treated groups and the control group. However, there was a substantial enhancement in the reduction of white blood cells (WBCs) and lymphocytes in the groups that received a maximum dosage of Lactuca.  In addition, Lactuca significantly increased the thrombocyte differential count, all blood lipid indicators, and liver enzyme markers compared to the control group. The rats who received doses of 400 and 800 mg/kg/bw exhibited significant histopathological damage in their liver, kidney, and spleen. In contrast, the rats given doses of 100 and 200 mg/kg/bw had normal organ structures. These findings may provide new and valuable information about the safe dosage range (100-400) of phenolic compounds from Lactuca that can be used in experiments with animals.

DOI

10.21608/ejvs.2024.300225.2209

Keywords

Fatty degeneration, Lactuca serriola, liver enzyme, Lymphocytic hyperplasia, Sharbazher district

Authors

First Name

Mohemmed

Last Name

Tofiq

MiddleName

-

Affiliation

Department of Medical Laboratory Analysis, College of Health Sciences, Cihan University, Sulaimani, 4601, KRG/Iraq.

Email

mohammed.salih@sulicihan.edu.krd

City

Sulaimani

Orcid

-

First Name

Mohemmed

Last Name

Salih

MiddleName

-

Affiliation

Department of Pharmacy, Kurdistan Technical Institute, Sulaimani, 4601, KRG/Iraq 3Department of Basic Science, College of Veterinary Medicine, University of Sulaimani, Sulaimani, 4601, KRG/Iraq.

Email

mohammad.salih@kti.edu.iq

City

Sulaimani

Orcid

-

First Name

Nawroz

Last Name

Kaka Rash

MiddleName

-

Affiliation

Department of Basic Science, College of Veterinary Medicine, University of Sulaimani, Sulaimani, 4601, KRG/Iraq.

Email

nawroz.kakarash@univsul.edu.iq

City

Sulaimani

Orcid

-

First Name

snur

Last Name

hassan

MiddleName

Amin

Affiliation

Anatomy and Histopathology Department, College of Veterinary Medicine, Iraq

Email

snur.amin@univsul.edu.iq

City

Sulaimani

Orcid

0000-0002-5751-0728

First Name

Rahel

Last Name

Ali

MiddleName

-

Affiliation

Department of Pharmacy, Kurdistan Technical Institute, Sulaimani, 4601, KRG/Iraq 3Department of Basic Science, College of Veterinary Medicine, University of Sulaimani, Sulaimani, 4601, KRG/Iraq.

Email

rahel.ali@kti.edu.iq

City

-

Orcid

-

First Name

Rebwar

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Clinic and Medicine, College of Veterinary Medicine, University of Sulaimani, Sulaimani, 4601, KRG/Iraq.

Email

rebwar.ahamed@univsul.edu.iq

City

-

Orcid

-

First Name

Hunar

Last Name

Wahid

MiddleName

-

Affiliation

Research Center Assistant, College of Veterinary Medicine, University of Sulaimani, Sulaimani, 4601, KRG/Iraq.

Email

hunar82.wahid@gmail.com

City

-

Orcid

-

Related Issue

-2

Receive Date

2024-06-29

Publish Date

2024-10-14

Page Start

1

Page End

13

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS3862331728853200.pdf

PDF . 4.6MB

Link

https://ejvs.journals.ekb.eg/article_386233.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=386233

Order

386,233

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Assessment of Toxicological Effect of Lactuca serriola L. in Sprague-Dawley Rat

Details

Type

Article

Created At

23 Dec 2024