In recent years, the world has become increasingly interested in medicinal plants. As a result, this research was conducted to identify the therapeutic value of the genus Frankenia and its relationship with its phytochemical constituents and biological activities. Frankenia is considered one of the most important medicinal plants that are rich in phytochemical constituents with biological activities. Frankenia is a flowering plant (Angiosperm) belonging to the family Frankeniaceae. Frankenia species are rich in secondary metabolites such as tannins, proanthocyanidin, phenolic acids, phenolic acid derivatives, flavonoids, flavonoids sulphated, trace lignans along with their sulphated derivatives, traces of alkaloids and other bioactive compounds.  These secondary metabolites showed promising therapeutic values, such as antioxidant, anti-cancer, hepatoprotective, anti-Alzheimer's disease, anti-inflammatory, antidiabetic, anti-bacterial, anti-fungal, neuroprotective, antiparasitic, cytotoxic, and antiviral activities. This review aims to provide an overview of the phytochemistry and biological activities of Frankeniaceae recently.