Vaccination process against lumpy skin disease (LSD) is considered the only effective method for the prevention and control of LSD in endemic areas, where neutralizing antibodies play an important role in long-term protection after vaccination. A total of 260 sera samples were collected from 20 bulls, their ages ranged from 9 to 12 months. These bulls were divided into groups (each group containing 10 bulls) in beef farms at Monsha^,t El kanater Aboghaleb, Giza Governorate, Egypt. This study was carried out from November 2022 to May 2023. One of these groups was vaccinated with the local strain (SERVAC CAPRI-C®) and the other was immunised with the imported strain (BOVIVAX LSD®). The serum sampling was carried out before vaccination and till 6 months with intervals 2 weeks after vaccination. Our study aimed to determine the efficacy of both vaccines in cattle immunity for evaluating vaccinated cattle's humeral immune response against the Neethling strain vaccine. Our results revealed that the titer of antibodies against BOVIVAX LSD® appeared to highly significantly increase (P>0.05) throughout the experiment when compared with (SERVAC CAPRI-C®) which showed a slight numerical increase and then significantly decreased at 24 weeks post-vaccination. Likewise, the vaccination process might slightly affect some parameters of liver dysfunctions mainly the alanine transaminase test. In conclusion, live attenuated BOVIVAX LSD® vaccine has a great ability to induce a high level of antibody titer with prolongation of immunity duration, so it is considered the best choice of vaccine for prevention and control of LSD that can applied in the field.