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383463

Pycnogenol and Its Nanoparticles: A Comparative Study of Their Effects on Growth, Gut Morphology, and mRNA Level of Lipid Metabolic Pathways and Antioxidant-Related Genes in Broi

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Physiology & Animal Nutrition

Abstract

This study aimed to find out how dietary supplementation with pycnogenol and its nanoparticles affected the growth performance, immune response, and antioxidant activity of broilers. In a 35-day feeding study, 150 one-day-old male avian chicks were randomly assigned to one of three nutrition regimens in three repetitions. The studied birds received a Pycnogenol free diet (Control), a Pycnogenol at 50 mg/kg diet (PYC), or a Nano-Pycnogenol at 50 mg/kg diet (Nano-PYC). At the end, Nano-Pycnogenol group demonstrated the highest growth performance among the groups followed by Pycnogenol group (P < 0.05). Concurrent with the improved duodenum and jejunum morphologies of the tested groups in comparison to control (P < 0.05). Additionally, there were significant decreases in triglyceride and very low-density lipoprotein levels (VLDL) and elevations in HDL cholesterol (P < 0.05). Furthermore, fatty acid synthetase (FAS), hormone-sensitive lipase (HSL), and lipoprotein lipase (LPL) levels and activities have been assessed, in addition to, super oxide dismutase (SOD), glutathione peroxidase (GPX), insulin like growth factor -1 (IGF-1), growth hormone (GHR) and myostatin mRNA expression levels and activities. All of these genes were found to be highly expressed in the Nano-PYC and PYC groups as compared to the control except FAS and Myostatin mRNA expression levels which demonstrated significantly lower levels, than the control group (P < 0.05). To sum up, giving a broiler a 50 mg/kg dose of Pycnogenol and its nanoparticles may improve the shape of its gut, and its immune system and antioxidant defences.

DOI

10.21608/ejvs.2024.306202.2269

Keywords

Broilers, pycnogenol, Nano- Pycnogenol, Growth performance, health status

Authors

First Name

Aya

Last Name

Elattar

MiddleName

-

Affiliation

Nutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516, Kafrelsheikh, Egypt

Email

elattaraya.og90@gmail.com

City

-

Orcid

-

First Name

Amr

Last Name

Zain

MiddleName

-

Affiliation

Nutrition department,Animal Health Research Institute,Agriculture Research Center,Egypt

Email

dramrzaineldin@gmail.com

City

kafrelsheikh

Orcid

-

First Name

Sahar

Last Name

Elnaggar

MiddleName

-

Affiliation

Animal wealth development Department, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516, Kafrelsheikh, Egypt

Email

saharvet1987@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Gewaily

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt

Email

drmahmoudsaad@gmail.com

City

-

Orcid

-

First Name

Foad

Last Name

Farrag

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt

Email

farragvet@gmail.com

City

-

Orcid

-

First Name

Edsokey

Last Name

Nassef

MiddleName

-

Affiliation

Nutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516, Kafrelsheikh, Egypt

Email

dsokynassef@yahoo.com

City

-

Orcid

-

First Name

Mustafa

Last Name

Shukry

MiddleName

-

Affiliation

Physiology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

Email

mustafashukry82@yahoo.com

City

-

Orcid

-

First Name

Abdelnasser

Last Name

Bakr

MiddleName

-

Affiliation

Nutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516, Kafrelsheikh, Egypt.

Email

bakrvet@hotmail.com

City

-

Orcid

-

First Name

Sayed

Last Name

Hegazi

MiddleName

-

Affiliation

Nutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516, Kafrelsheikh, Egypt.

Email

smhegazi57@hotmail.com

City

-

Orcid

-

Related Issue

-2

Receive Date

2024-07-22

Publish Date

2024-10-02

Page Start

1

Page End

15

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS3834631727816400.pdf

PDF . 2.0MB

Link

https://ejvs.journals.ekb.eg/article_383463.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=383463

Order

383,463

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Pycnogenol and Its Nanoparticles: A Comparative Study of Their Effects on Growth, Gut Morphology, and mRNA Level of Lipid Metabolic Pathways and Antioxidant-Related Genes in Broi

Details

Type

Article

Created At

23 Dec 2024