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Impact of Methanolic Extract of Pomegranate (Punica granatum L.) Seeds on Serum Biomarkers in Wistar Rats Fed High Cholesterol and Fructose Diet

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Physiology & Animal Nutrition

Abstract

Pomegranate has a potent antioxidant effect and anti-atherosclerotic activities. Also, it has a protective effect on different organs, such as the liver, heart, and skeletal muscle in obese rat models. This study aims to investigate the effect of pomegranate seed methanolic extract on lipid profile, renal function, and some blood parameters in high cholesterol / high fructose-fed rats. Four groups of ten male Wistar rats, A, B, C, and D, were created from the forty rats. As a negative control, Group A was fed a basal rat diet for six weeks. while groups B, C, and D were provided with 2% cholesterol added to the basal rat diet and +20% fructose in drinking water for four weeks (group B served as a positive control). After two weeks, groups C and D received 500 and 1000 mg of pomegranate methanolic extract/kg b.w/day, respectively; blood samples were collected at weeks 0, 2, 3, and 5.  Compared to group B, groups C and D's serum levels of urea, triglycerides, and total cholesterol had significantly decreased by the end of the experiment. Groups C and D exhibited higher HDL-C levels than Group B. In comparison to the other experimental groups, group C's serum creatinine levels dramatically dropped. The blood glucose levels in group D were much lower than in group B. The pomegranate seed extract positively influenced serum lipid profile and blood glucose and protected creatinine and urea levels in Wistar rats.

DOI

10.21608/ejvs.2024.292047.2115

Keywords

Hypercholesterolemia, pomegranate, Fructose, kidney

Authors

First Name

Ayat

Last Name

Osman

MiddleName

-

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum, 13314, Shambat, Sudan.

Email

ayatosman8922@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Alameen

MiddleName

Omer

Affiliation

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, 31982 Al-Ahsa, Saudi Arabia. Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum, 13314, Shambat, Sudan

Email

aomer@kfu.edu.sa

City

-

Orcid

0000-0003-3099-4328

First Name

Walieldin

Last Name

Elmgboul

MiddleName

Elsadig

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum, 13314, Shambat, Sudan.

Email

welsadig@yahoo.com

City

-

Orcid

-

First Name

Ibrahim

Last Name

Albokhadaim

MiddleName

-

Affiliation

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, 31982 Al-Ahsa, Saudi Arabia.

Email

ialbokhadaim@kfu.edu.sa

City

-

Orcid

0000-0002-8569-5571

First Name

Sameer

Last Name

Alhojaily

MiddleName

-

Affiliation

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, 31982 Al-Ahsa, Saudi Arabia

Email

salhojaily@kfu.edu.sa

City

-

Orcid

0000-0003-4035-2206

First Name

Saad

Last Name

Shousha

MiddleName

-

Affiliation

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, 31982 Al-Ahsa, Saudi Arabia. Department of Physiology, Faculty of Veterinary Medicine, Benha University, Benha, 3736, Egypt

Email

smmohamed@kfu.edu.sa

City

-

Orcid

0000-0001-6446-9359

First Name

Osama

Last Name

Ali

MiddleName

-

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum, 13314, Shambat, Sudan

Email

omasum2005@yahoo.de

City

-

Orcid

0000-0003-2967-5100

Related Issue

-2

Receive Date

2024-06-04

Publish Date

2024-08-25

Page Start

1

Page End

10

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS3760011724533200.pdf

PDF . 987.5kB

Link

https://ejvs.journals.ekb.eg/article_376001.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=376001

Order

376,001

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Impact of Methanolic Extract of Pomegranate (Punica granatum L.) Seeds on Serum Biomarkers in Wistar Rats Fed High Cholesterol and Fructose Diet

Details

Type

Article

Created At

23 Dec 2024