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372644

Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmacology & Toxicology

Abstract

One of the major limitations in ophthalmic delivery is the poor bioavailability of drugs from conventional eye drops. Pre-corneal drug loss factors include rapid tear turnover, transient residence time, and the relative impermeability of corneal epithelium. Occasionally, systemic absorption of drugs may result in systemic side effects.
To overcome these issues, controlled drug delivery systems were developed, including different types of in situ gel-forming systems based on different mechanisms (temperature, pH, or ion activated) using different polymers that have been explored for sustained ocular delivery. This study aims to formulate ocular drugs as loaded ionic and pH-activated in situ hydrogel formulas for controlled drug delivery systems aiming to increase the pre-corneal residence time and reduce the frequency of application, limit side effects, and improve patient adherence to therapy. This study will conduct biochemical and ophthalmological tests for combined lecithin, alginic acid, and chitosan-loaded prednisolone eye drops in an animal model of induced uveitis.

DOI

10.21608/ejvs.2024.293173.2125

Keywords

Lecithin, Chitosan, Alginic acid, Eye drops, uveitis

Authors

First Name

Amany

Last Name

Elshazly

MiddleName

H.M.

Affiliation

Pharmacology Department, Research Institute of Ophthalmology, Giza, Egypt.

Email

amany.namaky@gmail.com

City

-

Orcid

-

First Name

Ghada

Last Name

El-Hossary

MiddleName

Ghanem

Affiliation

Pharmacology Department, Research Institute of Ophthalmology, Giza, Egypt.

Email

gghossary@yahoo.com

City

-

Orcid

-

First Name

Amany

Last Name

Abdel-Ghaffar

MiddleName

-

Affiliation

Biochemistry Department, Research Institute of Ophthalmology, Giza, Egypt.

Email

amany300@hotmail.com

City

-

Orcid

-

First Name

Atef

Last Name

Mahmoud

MiddleName

Mohamed

Affiliation

Biochemistry Department, Research Institute of Ophthalmology, Giza, Egypt.

Email

atefmah18@gmail.com

City

-

Orcid

-

First Name

Leqaa

Last Name

Moemen

MiddleName

-

Affiliation

Biochemistry Department, Research Institute of Ophthalmology, Giza, Egypt.

Email

leqaa.moemen@yahoo.com

City

-

Orcid

-

First Name

Marwa

Last Name

Elfoly

MiddleName

-

Affiliation

Ophthalmology Department, Research Institute of Ophthalmology, Giza, Egypt.

Email

marwario2014@gmail.com

City

-

Orcid

-

First Name

Amal

Last Name

Elgohary

MiddleName

-

Affiliation

Ocular Physiology Department. Research Institute of Ophthalmology, Giza, Egypt.

Email

a-gohary@hotmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Ata

MiddleName

Mostafa

Affiliation

Biochemistry Department, Research Institute of Ophthalmology, Giza, Egypt.

Email

ahmed.mostafa1412@gmail.com

City

-

Orcid

0000-0003-1969-9707

Related Issue

-2

Receive Date

2024-05-28

Publish Date

2024-08-08

Page Start

1

Page End

14

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS3726441723064400.pdf

PDF . 1.6MB

Link

https://ejvs.journals.ekb.eg/article_372644.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=372644

Order

372,644

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits

Details

Type

Article

Created At

23 Dec 2024