Equine colic ranks among the most prevalent field problems in equine practice, and it's believed to be the leading cause of death for horses. This study was performed on sixty-four Arabian horses of both sexes (17 males and 47 females) ranging in age between 6 months to 26 years of which 15 clinically healthy horses joined as the control, and 32 horses are categorized in different colic groups. They were clinically evaluated on the basis of vital signs, intestinal sounds, gastric reflux, and findings of palpation per rectum. Hematology, coagulation profile, serum amyloid A (SAA), haptoglobin, venous blood gas (VBG), and electrolyte analysis were performed on jugular blood samples.    The results revealed a significant difference especially for SAA, fibrinogen, ionized calcium (iCa2⁺), anion gap (AG), and acid-base parameters between colic groups and the control group. In conclusion SAA, fibrinogen, and acid-base and electrolyte disturbances could be valuable indicators for the diagnosis and prognosis of colic with no significant value for haptoglobin. Our conclusion shows that SAA, fibrinogen, and acid-base and electrolyte disturbances could be valuable indicators for the diagnosis and prognosis of colic with no significant value for haptoglobin.