Physalisangulata fruit can be used to rescue fertility levels.Paracetamol is an analgesic but it can be fatal. It can reserve male fertility levelsspecifically, when a drug is abused as an analgesic but it has other pulchritudinous utilities. Paracetamol is one of those drugs commonly abused as an analgesic but it has fatal tendency which is obvious at high doses. However, its fortuity can be harnessed if administered in therapeutic doses. Otherwise, it can pretermit your life. This study assessed the protective effect of Physalisangulata fruit in rescuing the reproductive performance of laboratory  mice exposed to paracetamol(200mg/kg).Male mice aged 23 months of the white Swiss Balb/c strain were divided into 4 groups; the control group that was given normal saline, first group that had alcoholic extract of Physalisangulata fruit (200 mg/kg), while the other one was treated with alcoholic extract of P.angulata fruit and paracetamol (0.50 mg/kg) and the final group was given paracetamol alone (0.50 mg/kg).The result revealed that body weights, organ size for testis, epididymis, seminal vesicles and reproductive indices were significantly reduced as a result of paracetamol exposure. On the other hand, alcoholised fruit extract showed a protective effect on decreased sperm numbers, decreased cellularity, altered testicular histo-morphology following exposure to paracetamol. Seminiferous tubule morphological characteristic was changed to a thicker epithelial cell layer in testes. Hematoxylin-eosin staining technique revealed an improvement in testicular histomorphology after alcoholceived fruit extract with a seminiferous tubule morphological characteristic that is somewhat changed to a thicker epithelial cell layer in testes. Paracetamol significantly reduces the body weights and organ size involving testicles, epididymides and seminal vesicles as well as reproductive indices. At the same time, the alcoholic fruit extract showed protective effects on decreased sperm numbers, decreased cell numbers and alteration in reproductive organ histomorphology following paracetamol intoxication. There was an alteration of seminiferous tubule morphological characteristic to a thicker epithelial cell layer in testes. In conclusion, physalisangulata fruit may be useful in rescuing the destructive tendency of paracetamol that is commonly abused as an analgesic but it can reserve male fertility level, when properly administered medically at therapeutic doses. It can equally prevent possible expected complications that may manifest following overdose consequences.