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361833

Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmacology & Toxicology

Abstract

The immune system, a complex network of cells and chemicals, protects the body from foreign antigens. Zingerone offers significant benefits like antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Vitamin C, a potent antioxidant, shields crucial biomolecules like proteins, lipids, and nucleic acids. against oxidative damage. Forty rats were classified into control, Zingerone, vitamin C and Zingerone + vitamin C treated groups. Hematological, biochemical, gene expression, histological and Immunohistochemical investigation were used in the evaluation of both substances on the immune system. Zingerone and Vitamin C have demonstrated potential synergistic effects on blood parameters and immune function. Their antioxidant action may enhance erythropoiesis and protect against oxidative stress, while their influence on leukocyte populations could improve immune defense and regulate inflammation as well as modulate cytokine levels and surge CD4 and CD8 positive T-lymphocytes.  in conclusion These findings point to the complex interplay of dietary components in immune health and warrant further investigation for therapeutic potential.

DOI

10.21608/ejvs.2024.278575.1949

Keywords

Zingerone, vitamin c, Immunostimulant, Gene expression, Immunohistochemistry

Authors

First Name

Mohamed A

Last Name

El Adawy

MiddleName

A. El Adawy

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

Email

aladawya@yahoo.com

City

-

Orcid

-

First Name

Amera

Last Name

Abd El-Latif

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

Email

-

City

-

Orcid

-

First Name

Foad

Last Name

Farrag

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

Email

foad.farrag@yahoo.com

City

Kafrelsheikh

Orcid

-

First Name

Mustafa

Last Name

Shukry

MiddleName

-

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

Email

mostafa.ataa@vet.kfs.edu.eg

City

Kafrelsheikh

Orcid

0000-0003-2722-2466

First Name

Shafiqah H Braiji

Last Name

Braiji

MiddleName

H

Affiliation

East Jeddah General Hospita

Email

shafiqah_10@yahoo.com

City

-

Orcid

-

First Name

Abeer

Last Name

Hanafy

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

Email

hanafy_2010@yahoo.com

City

Kafrelsheikh

Orcid

-

Volume

56

Article Issue

7

Related Issue

48611

Issue Date

2025-07-01

Receive Date

2024-03-21

Publish Date

2025-07-01

Page Start

1,393

Page End

1,404

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS_Volume 56_Issue 7_Pages 1393-1404.pdf

PDF . 3.1MB

Link

https://ejvs.journals.ekb.eg/article_361833.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=361833

Order

361,833

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study

Details

Type

Article

Created At

23 Dec 2024