This study aims 
to reduce the harmful effects of the drug colchicine on male hormones using lipid nanotechnology after loading colchicine onto the Nano- lipid (SNL ) and confirming the loading by adopting several tests, including Efficiency of entrapment and loading of SNL, Scan and transmission electron microscope, Fourier transform infrared spectroscopy (FTIR), And X-ray diffraction (XRD) .
The study included 60 adult male rats were used in this study. The animals were split up into six groups, with ten animals in each group. First group, distilled water was administered as the control group, whereas oral colchicine (3 mg/kg body weight) was administered once a day. the second group The SNL  was administered orally to the third group once a day at 2ml.  whereas the fourth group (30 rats) was divided into three subgroups (10) rats for each subgroup treated with Nano-Lipid colchicine depending on the different concentrations of the drug. The doses were: The first subgroup with ( 1.5 mg/kg. body weight), the second subgroup with (3 mg/kg. body weight ) and the third subgroup with  (6 mg/kg. body weight).
The duration of treatment was 30 days after completion. the samples were taken blood, and hormone levels were examined. A decrease in LH hormone and FSH hormone and Testosterone hormone levels was observed in the groups that were dosed with colchicine, while in the groups that were dosed with colchicine loaded with Nano lipid there was a significant increase in hormone levels, especially when the increased concentration of Nano -lipid loaded with colchicine.
The current study demonstrated that Nano lipids reduce the undesirable effects of colchicine and improve its action.