This study investigated the use of the antibiotic lincomycin to treat necrotic enteritis in broilers in light of the growing public health concern around antibiotic resistance. with Analysis the possible mechanism involved in the result of lincomycin  on growth performance and carcass characteristics of broiler chicks via evaluating: Growth performance profile , Hematological profile, Liver and kidney functions, Immunological response, Histopathological examination of the GIT Tissue and re-isolation of Cl. perfringens from the infected chickens post-treatment The experiment was performed at lab. Animal house , Faculty of Vet. Medicine Zagazig University. The study was conducted on healthy one hundred and twenty, For this experiment, commercial Hubbard chickens that were one day old were obtained from Al-Kahira Poultry Company, located in the 10th of Ramadan city, Egypt. They split up into four groups. There are thirty broilers in each group. The allocation of the chickens was as follows:  First group: negative control group; fed on a basal diet only; second group: positive control group; fed on a basal diet and infected with 2 ml broth culture of Cl. perfringens type (1.9×10⁹ organism/mL) orally on 19t^h days old; third group: prophylaxis lincomycin; gave lincomycin (10 mg/kg B.wt.) in drinking water from the first day of the experiment until the end; and on the 19^th day old, gave an oral infection with 2 ml broth culture of Cl. perfringens (1.9×10⁹ organism/mL). Fourth group (therapeutic lincomycin): 2 milliliters of infected broth 1.9×10⁹ organism/ml was cultured orally on the 19^th day of life, and after the onset of infection symptoms, drinking water was treated with lincomycin (10 mg/kg B.w.) for five days. Our findings demonstrated a significant reduction in body weight, weight increase, erythrocytic count, hemoglobin content, PCV%, and serum proteins in broiler hens suffering from necrotic enteritis. Additionally, a noteworthy rise in feed conversion rate, leukocytic count, and the administration of lincomycin to infected broilers improved clinical symptoms and decreased the mortality rate to 8, 6, and 2%, respectively. Additionally, the hematobiochemical changes and performance were recovered. Therefore, using lincomycin as a preventive or therapeutic measure proved very beneficial for managing necrotic enteritis in broiler chicks.
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