This study aims to assess the density of bone with concentrated growth factors and advanced plasma rich fibrin in the bone defects that created surgically in the sheep's mandible by the use of radiographic assessment. Seven defects made in the bone with 4 mm depth and width in every side of the mandible of the eight sheep. The defects were filled with the following manner: from the proximal to the distal orientation; 1st , 2nd , 3rd , 4th , and  the 5th defect was full of CGF on the right side and A-FRF is  in the lift side, The 6th , and 7th left empty in order to filled with physiological clot. Histological examination of the defects of the bone was made to measure the bone density of the 4 intervals (3 days, 7 days, 21 days, 28 days), after the surgery. The result of densitometry analysis revealed a major distinction between the CGF group and the A-PRF group when compared to the control group at the all four intervals with the density of the bone being the highest in the CGF group followed by A-PRF group and the control group was the least one show improvement in the bone density. CGF group increased the density of the bone throughout the entire study period and as found by densitometry histological data.